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Search Results for " axl receptor tyrosine kinase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T4409	Gilteritinib	ASP2215	FLT , TAM Receptor , c-Kit
	Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...		FLT , TAM Receptor , c-Kit
T4349	Sitravatinib	MG516,MGCD516	Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
T9052	XL092	CL-092,JUN04542	VEGFR , c-Met/HGFR , TAM Receptor
	XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.		VEGFR , c-Met/HGFR , TAM Receptor
T1797	Cabozantinib S-malate	Cabozantinib,XL184,Cabozantinib Malate	Apoptosis , VEGFR , c-Met/HGFR , TAM Receptor , c-Kit
	Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity.		Apoptosis , VEGFR , c-Met/HGFR , TAM Receptor , c-Kit
T72574	Axl/Mer/CSF1R-IN-1
	Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.
T79969	Axl-IN-16		TAM Receptor
	Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1].		TAM Receptor
T77085	Mipasetamab
	Mipasetamab, an IgG1κ antibody, targets AXL, a tyrosine kinase receptor and TAM Receptor. It plays a crucial role in synthesizing ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC), known fo...
T80609	Mecbotamab
	Mecbotamab vedotin (BA3011) is a humanized IgG1-κ antibody engineered to target the AXL receptor tyrosine kinase (AXL). Serving as a conditionally active biologic (CAB), mecbotamab is conjugated to monomethyl auristatin ...
T12925	Sitravatinib malate	MGCD516 malate,MG-516 malate	TAM Receptor
	Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT...		TAM Receptor

Compounds

Gilteritinib

T4409

Synonym: ASP2215

Target: FLT, TAM Receptor, c-Kit

Sitravatinib

T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Cabozantinib

T2586

Synonym: XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cabozantinib hydrochloride

T5164

Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351

Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR

XL092

T9052

Synonym: CL-092,JUN04542

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cabozantinib S-malate

T1797

Synonym: Cabozantinib,XL184,Cabozantinib Malate

Target: Apoptosis, VEGFR, c-Met/HGFR, TAM Receptor, c-Kit

Target: TAM Receptor

Synonym: MGCD516 malate,MG-516 malate

Target: TAM Receptor

Cat No.	Product Name	Synonyms	Targets
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R

Natural Products

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01601	AXL Protein, Human, Recombinant (His)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-06552	AXL Protein, Rat, Recombinant (His)	Rat	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPJ-00449	AXL Protein, Human, Recombinant (hFc)	Human	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPJ-00399	AXL Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPY-01021	AXL Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-06478	AXL Protein, Human, Recombinant (mFc)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-01364	AXL Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signa...
TMPY-00882	Mer Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04330	Mer Protein, Human, Recombinant	Human	HEK293
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPK-00472	AXL Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00407	AXL Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00408	AXL Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00410	AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc)	Human	Human Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds...
TMPY-04999	GAS6 Protein, Human, Recombinant (His)
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds...
TMPJ-01081	Dtk Protein, Human, Recombinant (His)	Human	Human Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs an...
TMPJ-01143	MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)	Human	Human Cells
	Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one...
TMPY-04437	Mer Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-02291	Mer Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04363	Mer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...
TMPY-04747	Mer Protein, Human, Recombinant (aa 578-872)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-li...